Abstract:

 Objective To observe the effect of fundus laser combined with anisodine and triamcinolone acetonide on  hemodynamics of retinain ischemic central retinal vein occlusion. Design Prospective cases series. Participants 90 patients (90 eyes) with ischemic central retinal vein occlusion from January 2014 to October 2015 in Tongren Hospital.  Methods All the patients were randomly divided into group I, II, III, and treated with pan retinal laser photocoagulation (PRP) for 4 times, once a week. Group I was injected 1 ml (40 mg) triamcinolone acetonide in ipsilateral eye for once every 2 weeks. Group II was treated with 2 ml compound anisodine hydrobromide injection in superficial temporal artery subcutaneous for 30 days, once daily. Group III was treated with both anisodine and triamcinolone acetonide. Before and after treatment of 30 days, the hemodynamic parameters of the central retinal artery were detected with color Doppler ultrasonography. The best corrected visual acuity (BCVA) was measured by EDTRS visual acuity chart and the central macular thickness (CMT) was examined with optical coherence tomography (OCT). Main Outcome Measures The peak systolic velocity (PSV), end diastolic velocity (EDV) and the resistance index (RI) of the central retinal artery (CRA); maximum flow velocity (Vmax) and minimum flow velocity (Vmin) of the central retinal vein (CRV). Results The PSV and EDV of CRA in Ⅲ group were significantly higher than those in groupⅠand group Ⅱ (P<0.05). The RI in group III was lower than in groupⅠand group Ⅱ (P<0.05). Vmax and Vmin of the CRV in group III were significantly higher than those in group Ⅰand group Ⅱ (all P<0.05). The effect of visual of group III was significantly higher than that of group I and group II (P<0.05). CMT in group III was significantly lower than that in group I and II  (P<0.05). Conclusion Fundus laser combined with anisodine and triamcinolone acetonide can improve the hemodynamics of central retinal venous occlusion  and improve the curative effect. (Ophthalmol CHN, 2017, 26: 267-270)

Key words:  ischemic central retinal vein occlusion/therapy, hemodynamics of retina